The 6th federal electoral district of San Luis Potosí () is one of the 300 electoral districts into which Mexico is divided for elections to the federal Chamber of Deputies and one of seven such districts in the state of San Luis Potosí.
It elects one deputy to the lower house of Congress for each three-year legislative session by means of the first-past-the-post system. Votes cast in the district also count towards the calculation of proportional representation ("plurinominal") deputies elected from the second region.
Suspended in 1952, the 6th district was re-established as part of the 1977 electoral reforms, which increased the number of single-member seats in the Chamber of Deputies from 196 to 300. Under that plan, San Luis Potosí's seat allocation rose from five to seven. The two new districts were first contested in the 1979 legislative election.
The current member for the district, elected in the 2024 general election, is Juan Carlos Valladares Eichelmann of the Ecologist Green Party of Mexico (PVEM).
District territory.
Under the 2022 districting plan adopted by the National Electoral Institute (INE), which is to be used for the 2024, 2027 and 2030 federal elections, 
the 6th district comprises 179 electoral precincts () in the south-eastern portion of the municipality of San Luis Potosí, including most of its urban core. 
The city of San Luis Potosí, the state capital, serves as the district's head town (), where results from individual polling stations are gathered together and tallied. The district reported a population of 452,418 in the 2020 Census.
Previous districting schemes.
2017–2022
Between 2017 and 2022, the district comprised 175 precincts in the south-east of the municipality of San Luis Potosí.
2005–2017
Under the 2005 districting plan, the district covered 157 precincts in south-east of the municipality of San Luis Potosí.
1996–2005
From 1996 to 2005, the district covered the south of the municipality of San Luis Potosí, including the southern portion of the state capital.
1978–1996
The districting scheme in force from 1978 to 1996 was the result of the 1977 electoral reforms, which increased the number of single-member seats in the Chamber of Deputies from 196 to 300. Under that plan, San Luis Potosí's seat allocation rose from five to seven. The re-established sixth district's head town was at the city of San Luis Potosí and it covered a part of the city, the rural portion of its municipality, and the municipalities of Ahualulco, Moctezuma and Soledad Diez Gutiérrez.