The 4th federal electoral district of San Luis Potosí () is one of the 300 electoral districts into which Mexico is divided for elections to the federal Chamber of Deputies and one of seven such districts in the state of San Luis Potosí.
It elects one deputy to the lower house of Congress for each three-year legislative session by means of the first-past-the-post system. Votes cast in the district also count towards the calculation of proportional representation ("plurinominal") deputies elected from the second region.
The current member for the district, elected in the 2024 general election, is Francisco Adrián Castillo Morales of the National Regeneration Movement (Morena).
District territory.
Under the 2022 districting plan adopted by the National Electoral Institute (INE), which is to be used for the 2024, 2027 and 2030 federal elections, 
the 4th district shares the eastern portion of the state with the 7th district. It covers 333 electoral precincts () across 12 of the state's municipalities:
The district's head town (), where results from individual polling stations are gathered together and tallied, is at Ciudad Valles. The district reported a population of 419,880 in the 2020 Census.
Previous districting schemes.
2017–2022 
Between 2017 and 2022, the district was further east within the state. It covered seven municipalities: Ciudad Valles, Ébano, San Vicente Tancuayalab, Tamasopo, Tamuín, Tanquián de Escobedo and El Naranjo. The head town was at Ciudad Valles.
2005–2017
Under the 2005 districting plan, the district had its head town at Ciudad Valles and it covered eight municipalities: Ciudad Valles, Ébano, El Naranjo, San Vicente Tancuayalab, Santa Catarina, Tamasopo, Tamuin and Tanquián de Escobedo. 
1996–2005
From 1996 to 2005, the district had its head town at Ciudad Valles and it covered nine municipalities: the same eight as in the 2005 scheme, plus Tanlajás. 
1978–1996
The districting scheme in force from 1978 to 1996 was the result of the 1977 electoral reforms, which increased the number of single-member seats in the Chamber of Deputies from 196 to 300. Under that plan, San Luis Potosí's seat allocation rose from five to seven. The fourth district's head town was at Ciudad del Maíz and it covered the municipalities of Alaquines, Aquismón, Armadillo de los Infante, Cárdenas, Cerritos, Cerro de San Pedro, Ciudad del Maíz, Guadalcázar, Lagunillas, Rayón, San Ciro de Acosta, Santa Catarina, Tamasopo and Villa Juárez.