The 2nd federal electoral district of San Luis Potosí () is one of the 300 electoral districts into which Mexico is divided for elections to the federal Chamber of Deputies and one of seven such districts in the state of San Luis Potosí.
It elects one deputy to the lower house of Congress for each three-year legislative session by means of the first-past-the-post system. Votes cast in the district also count towards the calculation of proportional representation ("plurinominal") deputies elected from the second region.
The current member for the district, elected in the 2024 general election, is José Luis Fernández Martínez of the Ecologist Green Party of Mexico (PVEM).
District territory.
Under the 2022 districting plan adopted by the National Electoral Institute (INE), which is to be used for the 2024, 2027 and 2030 federal elections, 
the second district is situated to the north and east of the state capital, the city of San Luis Potosí. It covers 140 electoral precincts () across four of the state's municipalities:
The district's head town (), where results from individual polling stations are gathered together and tallied, is the state's second largest city, Soledad de Graciano Sánchez. The district reported a population of 372,779 in the 2020 Census.
Previous districting schemes.
2017–2022
Between 2017 and 2022, the district comprised seven municipalities located to the north, east and south of the state capital: Cerro de San Pedro, Santa María del Río, Soledad de Graciano Sánchez, Tierra Nueva, Villa de Arriaga, Villa de Reyes and Zaragoza. The head town was at Soledad de Graciano Sánchez.
2005–2017
Under the 2005 plan, the district covered eight municipalities: the 2017 scheme's seven, plus Armadillo de los Infante. 
1996–2005
From 1996 to 2005, the district covered 11 municipalities: the same group as in the 2005 scheme, plus Ahualulco, Mexquitic de Carmona and Villa Hidalgo.
1978–1996
The districting scheme in force from 1978 to 1996 was the result of the 1977 electoral reforms, which increased the number of single-member seats in the Chamber of Deputies from 196 to 300. Under that plan, San Luis Potosí's seat allocation rose from five to seven. The second district covered the municipalities of Catorce, Cedral, Charcas, Matehuala (the head town), Salinas, Santo Domingo, Vanegas, Venado, Villa de Arriaga, Villa de Guadalupe, Villa de La Paz, Villa de Ramos and Villa Hidalgo.