Katarzyna Piter and Mayar Sherif defeated Anna Danilina and Irina Khromacheva in the final, 7–6(7–2), 7–5 to win the doubles title at the 2025 Mérida Open. It was the fourth WTA Tour doubles title for Piter and second for Sherif.
Quinn Gleason and Ingrid Martins were the reigning champions. but Martins did not participate this year. Gleason partnered Emily Appleton, but lost in the first round to Danilina and Khromacheva.