The 2025 Copa Sudamericana final stages will be played from 15 July to 22 November 2025. A total of 24 teams will compete in the final stages to decide the champions of the 2025 Copa Sudamericana, with the final to be played at Estadio Ramón Tahuichi Aguilera in Santa Cruz de la Sierra, Bolivia.
Qualified teams.
The winners and runners-up of each of the eight groups in the Copa Sudamericana group stage as well as the third-placed teams of each of the eight groups in the Copa Libertadores group stage advanced to the final stages. The eight Copa Sudamericana group runners-up will face the eight Copa Libertadores group third-placed teams in the knockout round play-offs, whilst the eight Copa Sudamericana group winners directly advanced to the round of 16.
<section begin=Qualified teams />
Seeding.
<section begin=Seeding />
For the final stages, the teams were seeded according to their results in the group stage, with the Copa Sudamericana group winners seeded 1–8, the Copa Sudamericana group runners-up seeded 9–16, and the Copa Libertadores group third-placed teams seeded 17–24. For the round of 16 draw, the seeds 1–8 made up Pot 1, and the eight knockout round play-offs winners (seeds 9–24) made up Pot 2, keeping their seed. Teams from the same association may play each other from the knockout round play-offs onwards.
<section end=Seeding />
Format.
<section begin=Format />
Starting from the knockout round play-offs, the teams play a single-elimination tournament with the following rules:
Draw.
<section begin=Draw />
The draw for the round of 16 was held on 2 June 2025, 12:00 PYT () at the CONMEBOL headquarters in Luque, Paraguay. For the round of 16, the 16 teams were drawn into eight ties (A–H) between a Copa Sudamericana group winner (Pot 1) and a knockout round play-offs winner (Pot 2), with the group winners hosting the second leg. Teams from the same association or the same group could be drawn into the same tie (Regulations Article 2.2.3.2).<section end=Draw />
Bracket.
The bracket starting from the round of 16 is determined as follows:
<section begin=Bracket />
The bracket was decided based on the round of 16 draw, which was held on 2 June 2025.
<section end=Bracket />
Knockout round play-offs.
Summary.
The first legs will be played on 15–17 July, and the second legs will be played on 22–24 July 2025.
<section begin=Knockout round play-offs /><section end=Knockout round play-offs />
Matches.
"Winner advances to the round of 16."
"Winner advances to the round of 16."
"Winner advances to the round of 16."
"Winner advances to the round of 16."
"Winner advances to the round of 16."
"Winner advances to the round of 16."
"Winner advances to the round of 16."
"Winner advances to the round of 16."
Round of 16.
Summary.
The first legs will be played on 12–14 August, and the second legs will be played on 19–21 August 2025.
<section begin=Round of 16 /><section end=Round of 16 />
Matches.
"Winner advances to the quarter-finals (Match S1)."
"Winner advances to the quarter-finals (Match S2)."
"Winner advances to the quarter-finals (Match S3)."
"Winner advances to the quarter-finals (Match S4)."
"Winner advances to the quarter-finals (Match S4)."
"Winner advances to the quarter-finals (Match S3)."
"Winner advances to the quarter-finals (Match S2)."
"Winner advances to the quarter-finals (Match S1)."
Quarter-finals.
Summary.
The first legs will be played on 16–18 September, and the second legs will be played on 23–25 September 2025.
<section begin=Quarter-finals />
<section end=Quarter-finals />
Matches.
"Winner advances to the semi-finals (Match F1)."
"Winner advances to the semi-finals (Match F2)."
"Winner advances to the semi-finals (Match F2)."
"Winner advances to the semi-finals (Match F1)."
Semi-finals.
Summary.
The first legs will be played on 21–23 October, and the second legs will be played on 28–30 October 2025.
<section begin=Semi-finals />
<section end=Semi-finals />
Matches.
"Winner advances to the final."
"Winner advances to the final."
Final.
The final will be played on 22 November 2025 in Santa Cruz de la Sierra, Bolivia.