The 1980–81 WFA Cup was an association football knockout tournament for women's teams, held between 5 October 1980 and 10 May 1981. It was the 11th season of the WFA Cup and was won by Southampton, who defeated St Helens in the final.
The tournament consisted seven rounds of competition proper.
"All match results and dates from the Women's FA Cup Website."
Group A.
First round proper.
All games were scheduled for 5 and 12 October 1980.
Second round proper.
All games were originally scheduled for 2 November 1980.
Third round proper.
All games were originally scheduled for 7 December 1980.
Group B.
First round proper.
All games were scheduled for 5 and 12 October 1980.
Second round proper.
All games were originally scheduled for 2 November 1980.
Third round proper.
All games were originally scheduled for 7 December 1980.
Group C.
First round proper.
All games were scheduled for 5 and 12 October 1980.
Second round proper.
All games were originally scheduled for 2 November 1980.
Third round proper.
All games were originally scheduled for 7 December 1980.
Group D.
First round proper.
All games were scheduled for 5 and 12 October 1980.
Second round proper.
All games were originally scheduled for 2 November 1980.
Third round proper.
All games were originally scheduled for 7 December 1980.
Group E.
First round proper.
All games were scheduled for 5 and 12 October 1980.
Second round proper.
All games were originally scheduled for 2 November 1980.
Third round proper.
All games were originally scheduled for 7 December 1980.
Group F.
First round proper.
All games were scheduled for 5 and 12 October 1980.
Second round proper.
All games were originally scheduled for 2 November 1980.
Third round proper.
All games were originally scheduled for 7 December 1980.
Group G.
First round proper.
All games were scheduled for 5 and 12 October 1980.
Second round proper.
All games were originally scheduled for 2 November 1980.
Third round proper.
All games were originally scheduled for 7 December 1980.
Group H.
First round proper.
All games were scheduled for 5 and 12 October 1980.
Second round proper.
All games were originally scheduled for 2 November 1980.
Third round proper.
All games were originally scheduled for 7 December 1980.
Fourth round proper.
All games were originally scheduled for 4 January 1981.
Quarter–finals.
All games were played on 8 March 1981.
Semi–finals.
All games were played on 5 April 1981.