Emma Navarro defeated Emiliana Arango in the final, 6–0, 6–0 to win the singles title at the 2025 Mérida Open. She did not drop a set en route to her second WTA Tour title and first WTA 500 title. She became the fifth player to win a WTA final with a 'double bagel' scoreline since 2000, and the first since Iga Świątek defeated Karolína Plíšková at the 2021 Italian Open.
Zeynep Sönmez was the defending champion, but lost in the quarterfinals to Navarro.
Seeds.
The top four seeds received a bye into the second round.