phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase, known also as Cyclic phosphate dihydrolase is a hydrolase enzyme found in various species of bacteria. The enzyme uses water to catalyze the hydrolysis of a cyclic ribophosphate to form alpha-D-ribose 1,5-bisphosphate. Formally, the enzyme catalyzes the following chemical reactions,
"alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O = D-ribose 2,5-bisphosphate + H+"
"D-ribose 2,5-bisphosphate + H2O = D-ribose 5-phosphate + phosphate + H+"
In "Eggerthella lenta", "Gordonibacter urolithinfaciens" and "Gordonibacter pamelaeae", the enzyme is encoded by the gene "phnPP". The protein consists of 252 amino acids. The enzyme is known to have metal-ion binding sites for Mn2+ and Zn2+. The enzyme is involved in the catabolism of organophosphonates.