The 2025 Challenger Città di Lugano, known as 4° Città di Lugano, was a professional tennis tournament played on indoor hardcourts. It was the fifth edition of the tournament which was part of the 2025 ATP Challenger Tour. It took place in Lugano, Switzerland between 24 February and 2 March 2025.
Singles main-draw entrants.
Other entrants.
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as special exempts:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers: