San Lázaro was a Spanish mission in the Sonoran desert.
Located in the Santa Cruz River valley, the European settlement was founded as a cattle ranch by José Romo de Vivar. The mission was founded by Jesuit missionary Eusebio Kino about 1695, and was at various times a of Mission Nuestra Señora del Pilar y Santiago de Cocóspera, Mission Santa María Suamca, or Mission Nuestra Señora de los Dolores.
Kino oversaw the building of a mission church in 1706. John Ross Browne sketched the mission in 1864. By the late 1860s, it was deserted due to Apache raids.