The 2001 Open de España Villa de Madrid, also known as the WTA Madrid Open, was a professional women's tennis tournament played on outdoor clay courts at the Club de Campo Villa de Madrid in Madrid, Spain from 21 May until 26 May 2001. It was the sixth edition of the tournament and was classified as a Tier III event on the 2001 WTA Tour. Second-seeded Arantxa Sánchez Vicario won the singles title and earned $27,000 first-prize money.
Finals.
Singles.
 Arantxa Sánchez Vicario defeated Ángeles Montolio, 7–5, 6–0
Doubles.
 Virginia Ruano Pascual / Paola Suárez defeated Lisa Raymond / Rennae Stubbs, 7–5, 2–6, 7–6(7–4)