Andrew Karpen (April 18, 1966 – April 28, 2025) was an American independent film executive and producer. He was the founder and CEO of Bleecker Street. He was previously the co-CEO of Focus Features. He was an executive producer for the films "Denial" (2016), "The Man Who Invented Christmas" (2017), "The Last Word" (2017), "The Art of Self-Defense" (2019), "Golda" (2023), "The Return" (2024), and "Hard Truths" (2024).
Karpen died of glioblastoma in Fairfield County, Connecticut, on April 28, 2025, at the age of 59.