The 1972 Harding Bisons football team represented Harding College as member of the Arkansas Intercollegiate Conference (AIC) during the 1972 NAIA Division I football season. Led by ninth-year head coach John Prock, the Bisons compiled an overall record of 10–1 with mark of 5–1 in conference play, sharing the AIC title with . Harding was invited to the Cowboy Bowl, where the Bisons defeated . Harding was ranked sixth in the final NAIA Division I poll.
The 1972 team was the first in program history to win a conference championship. The AIC title was the first of two that Harding won during Prock's tenure, the other coming four years later, in 1976.
Junior star running back Alan Dixon was selected in the 14th round of the 1974 NFL draft by the Minnesota Vikings and started against the Denver Broncos in an exhibition game. He later played for the expansion Seattle Seahawks. All-American quarterback Tom Ed Gooden was selected in the 11th round of the 1974 NFL draft by the Cleveland Browns.