The 2025 season will be São Paulo's 96th season in the club's history and their 65th in the top-flight of Brazilian football. Along with Série A, São Paulo compete in the Campeonato Paulista, Copa do Brasil and Copa Libertadores.
Competitions.
FC Series.
São Paulo FC held the pre-season in Florida, United States, like other Brazilian teams (Atlético Mineiro, Cruzeiro and Flamengo), facing the latter two in the following matches:
Copa Libertadores.
Group stage.
The draw for the group stage was held on 17 March 2025, 20:00 PYST (), at the CONMEBOL Convention Centre in Luque, Paraguay.
Round of 16.
The draw for the round of 16 was held in 2 June, 12:00 PYST (), at the CONMEBOL Convention Centre in Luque, Paraguay.
Série A.
Matches.
The league fixtures was announced on 12 February 2025.