The 2012 Indianapolis Greyhounds football team represented the University of Indianapolis (UIndy) during the 2012 NCAA Division II football season as a member of the Great Lakes Valley Conference (GLVC). Led by third-year head coach Bob Bartolomeo, the Greyhounds finished with an overall record of 10–3, going a perfect 8–0 in GLVC play. The team played its home games at Key Stadium in Indianapolis, Indiana. Head coach Bob Bartolomeo was named the GLVC coach of the year.
The 2012 season featured many firsts for the program. The Greyhounds finished the regular season with 9 wins, the most in program history at the time. The Greyhounds also received their first NCAA Division II playoff berth. In the first round, the Greyhounds defeated Midwestern State 31–14, before falling to top-ranked CSU Pueblo, 7–28, in the second round.