Flufenoxine (F-98214-TA) is a Serotonin–norepinephrine reuptake inhibitor. It can be used to treat disorders of the central nervous system, particularly depression and anxiety. It was developed by a Spanish company at the beginning of the 21st century.
Flufenoxine derivatives have been patented for the treatment of Alzheimer's disease.
Analogues of Flufenoxine were reported containing a duloxetine-type thiophene surrogate ring moiety. Such agents possess the desired "triple"-mode of activity (serotonin-noradrenaline and dopamine) (cf. SNDRI).
For another related SNDRI agent see PC71812205. The racemic agent had IC50's of 11, 14, 190nM S~N>D.