Once Upon a Time in Panama (Spanish: Érase una vez en Panamá) is a 2024 Panamanian comedy film written, co-produced, starred and directed by Elmis Castillo. It premiered on March 21, 2024, in Panamanian theaters. Synopsis. Ermisendo, a janitor, opens the door to his boss Domingo and is unjustly accused of the largest fentanyl theft in Panamanian history. This sends Ermisendo on the run until he meets Tito, a former bushrangers, who tells him his life story about how he managed to dismantle a child trafficking ring by doing the right thing. This inspires Ermisendo to confront those who framed him... but at what cost? Production. Principal photography wrapped on January 9, 2024, lasting 18 days in Volcán Barú, Chorcha, and Bayano Caves. Reception. In its second week in theaters, the film sold 30,000 tickets.