Local elections were held in Cagayan on May 12, 2025, as part of the 2025 Philippine general election. Cagayan voters elected a governor, a vice governor, and 10 out of 13 members of the Cagayan Provincial Board.
Governor.
Term-limited incumbent Manuel Mamba (Nacionalista Party) is running for vice governor of Cagayan. Manuel was re-elected with 52.02% of the vote in 2022.
Candidates.
The following candidates are included in the ballot:
Vice governor.
Term-limited incumbent Melvin Vargas Jr. (Independent) is running for governor of Cagayan. Vargas was re-elected under PDP–Laban with 34.94% of the vote in 2022.
Candidates.
The following candidates are included in the ballot:
Provincial Board.
The Cagayan Provincial Board is composed of 13 board members, 10 of whom are elected.
Retiring and term-limited board members.
The following board members are retiring:
The following board members are term-limited:
1st provincial district.
Cagayan's 1st provincial district consists of the same area as Cagayan's 1st legislative district. Three board members are elected from this provincial district.
Candidates.
The following candidates are included in the ballot:
2nd provincial district.
Cagayan's 2nd provincial district consists of the same area as Cagayan's 2nd legislative district. Three board members are elected from this provincial district.
Candidates.
The following candidates are included in the ballot:
3rd provincial district.
Cagayan's 3rd provincial district consists of the same area as Cagayan's 3rd legislative district. Four board members are elected from this provincial district.
Candidates.
The following candidates are included in the ballot:
Election-related incidents.
In February 11, 2025, three people were arrested for trying to extort from two municipal candidates in Enrile by claiming to be COMELEC-connected IT specialists who could rig the election results in their favor. 
On April 23, Joel Ruma, the reelectionist mayor of Rizal, was shot dead by a suspected sniper while campaigning, with three people injured in the same incident.