Uzma Samadani is an American neuroscientist, entrepreneur and neurosurgeon, who practices in Minneapolis, Minnesota at the Minneapolis VA Health Care System and is President and CEO of US Neurosurgery Associates, a private neurosurgical practice. She is the founder of Oculogica, Inc.
Education.
Samadani graduated from the University of Wisconsin-Madison with double majors in English and Molecular Biology. She obtained her PhD and MD from the University of Illinois. She completed her internship, residency, and chief residency in neurosurgery at the University of Pennsylvania.  
Career.
Samadani was a Van Wagenen fellow in Goettingen Germany where she performed research with Prof Dr. Veit Rohde. She took a position at the New York Harbor HealthCare System (Manhattan VA) where she became Chief of Neurosurgery. During the aftermath of Hurricane Sandy on October 27, 2012 she led the neurosurgery service to perform 266 neurosurgical cases at the Bronx and Brooklyn VAs while the Manhattan VA was being restored after flood damage up to the third floor. She was an Assistant Professor in Neurosurgery, Psychiatry, and Physiology and Neurosciences at New York University while in New York City, as well as CoDirector of the Cohen Veterans Center. The NYT featured one of her patients in an article on management of bleeding on the surface of the brain.
In July of 2015, she moved to the Midwest to become the Rockswold Kaplan Endowed Chair at Hennepin County Medical Center and continued to work at the VA in Minneapolis, Minnesota. While at HCMC she advocated for early intervention for spinal cord injury to optimize outcome and for clinical trials to improve outcomes. In conjunction with ophthalmologists at HCMC, Samadani removed a wooden spike from the brain and skull of a man who had been impaled through the orbital rim and skull in a manner reminiscent of Phineas Gage. She later reconstructed his skull with a partially 3D printed skull substitute. On April 23, 2017 the Minnesota Star Tribune published an article about a 28 hour surgery Samadani performed to resect 5 ependymoma tumors from the spine of 15 year Guadalupe Galeno-Rodriguez. The patient was still tumor free 5 years later. In 2018, she was featured on the cover of Minneapolis St Paul Magazine with the headline “The Doctor Will Save You Now. 
She is currently in private neurosurgery practice as President and CEO of US Neurosurgery Associates. 
Samadani is also a neuroscientist whose career has focused on objective classification and treatment of brain and spinal cord injury. She developed an eye tracking diagnostic that assesses pupil size and movement and founded the company Oculogica Inc. Oculogica has obtained 5 FDA clearances for EyeBox, an aide in the diagnosis of concussion.
Samadani was also an early investigator of the use of epidural spinal cord stimulation to treat spinal cord injury. Her first private practice patient, Traci Fernandez, who is paraplegic from a spinal cord injury due to transverse myelitis,  stood up on stage at the 2023 Annual Unite to Fight Paralysis Meeting to demonstrate advances in epidural spinal cord stimulation.